Sildenafil inhibits PDE5, which is an enzyme that destroys cGMP. These include sildenafil (commonly known by the brand name Viagra), tadalafil (Cialis), vardenafil (Levitra) and avanafil (Stendra). Erectile dysfunction refers specifically to problems achieving or maintaining an erection. Desperation has pushed many patients towards unscrupulous private clinics around the world, who promise an ultimate cure, offering treatments like shockwaves, stem cell infusions and injections of platelet-rich plasma on an unregulated basis. Experts say stress, depression, poor self-esteem, and performance anxiety can impair the ability to have an erection. Like other ED medications, avanafil can interact with some medications used to treat high blood pressure and other cardiovascular conditions, including nitrates. It works by increasing the flow of blood to the penis so that a man can get an erection when he is sexually stimulated. You should always buy cialis online from an online pharmacy which is fully registered.
When the muscle is relaxed, more blood can flow into the penis and fill the spaces in the penis. These drugs are classified as phosphodiesterase-5 inhibitors (PDE-5) – which enable an erection, temporarily, but are not the best for maintaining an erection over time. For these men the Internal Penile Implant is currently the best option. Scientists are still not entirely sure how or why it works, but so far they think it leads to a form of regeneration of the erectile tissue, promoting the growth of new blood vessels and clearing plaque from existing vessels. However, over time, these medications may stop working as well as they did previously. Such circulatory problems are the number one cause of erectile dysfunction. But if your ability to achieve an erection becomes unpredictable, meaning it’s not possible to get one during the times when you want to have sex, you may be looking at a symptom of ED—even if you’re able to get an erection once in awhile. Often, age is a predominant factor in erectile dysfunction; however, your chronological age is not solely responsible for ED’s development. Nitric oxide enables the production of cGMP, which controls the dilation and contraction of the blood vessels that carry blood to and from the penis.